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Title: Genome-wide patterns of selection in 230 ancient Eurasians
Authors: Mathieson, Iain
Lazaridis, Iosif
Rohland, Nadin
Mallick, Swapan
Patterson, Nick
Alpaslan Roodenberg, Songül
Harney, Eadaoin
Stewardson, Kristin
Fernandes, Daniel M.
Novak, Mario
Sirak, Kendra A.
Gamba, Cristina
Jones, Eppie Ruth
Llamas, Bastien
Dryomov, Stanislav V.
Pickrell, Joseph K.
Arsuaga, Juan Luis
Bermúdez de Castro, José María
Carbonell, Eudald
Gerritsen, Fokke A.
Khokhlov, Aleksandr
Kuznetsov, Pavel
Lozano Ruiz, Marina
Meller, Harald
Mochalov, Oleg D.
Moiseyev, Vyacheslav G.
Rojo Guerra, Manuel A.
Roodenberg, Jacob J.
Vergès Bosch, Josep María
Krause, Johannes
Cooper, Alan
Alt, Kurt W.
Brown, Dorcas R.
Anthony, David W.
Lalueza Fox, Carles
Haak, Wolfgang
Pinhasi, Ron
Reich, David E.
Keywords: Evolutionary genetics;Genomics;Population genetics
Issue Date: Nov-2015
Publisher: Nature Publishing Group
Citation: Nature, 2015, 528, 499-503
Abstract: Ancient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 bc, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe’s first farmers. We also report a transect of the steppe region in Samara between 5600 and 300 bc, which allows us to identify admixture into the steppe from at least two external sources. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.
ISSN: 0028-0836
DOI: 10.1038/nature16152
Type: Article
Appears in Collections:Paleobiología

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