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Title: Body composition analysis as an indirect marker of skeletal muscle mass in Huntington's disease
Authors: Cubo-Delgado, Esther
Rivadeneyra Posadas, Jéssica
Gil-Polo, Cecilia
Armesto Formoso, Diana
Mateos Cachorro, Ana
Mariscal Pérez, Natividad
Keywords: Body composition;Huntington’s disease;Body mass index;Skeletal muscle;Fat-free mass;Fat mass;Bioimpedancy;Energy
Issue Date: Nov-2015
Publisher: Elsevier
Citation: Journal of the Neurological Sciences, 2015, 358 (1-2), 335-338
Abstract: Background Skeletal muscle wasting is likely to play an important role in the Huntington's disease (HD) pathogenesis. Our aim was to analyze the body composition, and specifically fat-free mass (FFM), as an indirect marker of skeletal muscle in patients with HD, and its association with HD severity and energy balance. Methods Cross-sectional, case–control study. Body composition was analyzed using bioelectrical impedance. Information was collected as regards of the anthropometrics, disease severity [Unified Huntington Disease Rating (UHDRS) and Total functional capacity (TFC) scores], CAG repeats, protein catabolism, energy intake and energy expenditure. Results Twenty two patients with HD [mean age 50.3 ± 15.6, mean UHDRS of 27.9 ± 23.7, median TFC of 11 (IQR: 7; 13); median body mass index 23.6 (IQR: 26.8; 22.5)], and 18 controls were included. Both groups were similar in terms of age, gender, body mass index, body composition, physical activity level, and protein catabolism. FFM was correlated with energy intake (r = 0.73, p < 0.001), resting energy expenditure (r = 0.64, p = 0.001) and physical activity (r = 0.54, p = 0.003), but not with CAG repeats, or HD severity. Conclusions Our results do not support the presence of significant muscle wasting in patients with early-moderate Huntington's disease. However, to prevent muscle wasting in HD, dietary strategies, in addition to physical exercise, should be further investigated.
ISSN: 0022-510X
DOI: 10.1016/j.jns.2015.09.351
Type: Article
Appears in Collections:Paleobiología
Bioenergía y Análisis del Movimiento

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